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Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody

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Antigen
Synonyms IL-17B, IL-20, NIRF, ZCYTO7, RNF107, URF2, 2310065A22Rik, AI426270, AW214556, D130071B19Rik, Nirf
Epitope
AA 81-181
(15), (15), (11), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(62), (25), (22), (2), (2), (1), (1)
Host
Mouse
(56), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(49), (25), (13), (11), (11), (5), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen UHRF2 (NP_690856, 81 a.a. ~ 181 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A11
Isotype IgG2b kappa
Specificity UHRF2 (NP_690856, 81 a.a. ~ 181 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UHRF2 (UHRF2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 89985 DA
Gene ID 12406
NCBI Accession NP_690856
Research Area Ubiquitin-related antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody (ABIN393647) Western Blot analysis of UHRF2 expression in transfected 293T cell line by UHRF2 mono...
Immunohistochemistry (IHC) image for anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody (ABIN393647) anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody (Image 2)
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

He, Duan, Chen et al.: "Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells." in: FEBS letters, Vol. 583, Issue 21, pp. 3501-7, 2009 (PubMed).

Iwata, Nagashima, Matsumoto et al.: "Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9796-803, 2009 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).

Catalog No. ABIN393647
$450.00
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