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Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody

Details for Product No. ABIN393647, Supplier: Login to see
Antigen
  • IL-17B
  • IL-20
  • NIRF
  • ZCYTO7
  • RNF107
  • URF2
  • 2310065A22Rik
  • AI426270
  • AW214556
  • D130071B19Rik
  • Nirf
Epitope
AA 81-181
15
15
11
4
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
62
25
22
2
2
1
1
Host
Mouse
56
8
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
49
25
13
11
11
5
1
1
1
Supplier
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Immunogen UHRF2 (NP_690856, 81 a.a. ~ 181 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A11
Isotype IgG2b kappa
Specificity UHRF2 (NP_690856, 81 a.a. ~ 181 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UHRF2 (UHRF2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 89985 DA
Gene ID 12406
NCBI Accession NP_690856
Research Area Ubiquitin-related antibodies, Protein Modifications, Cancer, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody (ABIN393647) Western Blot analysis of UHRF2 expression in transfected 293T cell line by UHRF2 mono...
Immunohistochemistry (IHC) image for anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody (ABIN393647) anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) (AA 81-181) antibody (Image 2)
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

He, Duan, Chen et al.: "Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells." in: FEBS letters, Vol. 583, Issue 21, pp. 3501-7, 2009 (PubMed).

Iwata, Nagashima, Matsumoto et al.: "Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9796-803, 2009 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).