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Adenylate Kinase 1 antibody (AK1) (AA 1-195)

Details for Product anti-AK1 Antibody No. ABIN393655, Supplier: Login to see
Antigen
  • ADK-1
  • AK1
  • CG17146
  • DAK1
  • Dak1
  • Dmel\\CG17146
  • adk1
  • bs34e10.y1
  • ak5
  • ADENYLATE KINASE 1
  • MLE2.3
  • MLE2_3
  • adenylate kinase 1
  • Ak-1
  • B430205N08Rik
  • Ak 1
  • zgc:91930
  • Myokinase
Epitope
AA 1-195
22
17
10
7
4
4
3
2
1
1
1
1
Reactivity
Human
116
38
34
12
11
3
3
2
2
2
1
1
Host
Mouse
97
29
12
Clonality (Clone)
Monoclonal ()
Conjugate
This Adenylate Kinase 1 antibody is un-conjugated
12
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
114
69
45
31
13
13
11
9
8
7
6
5
5
2
1
1
Supplier
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Immunogen AK1 (AAH01116, 1 a.a. ~ 195 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A6-1F5
Isotype IgG1 kappa
Specificity AK1 (AAH01116, 1 a.a. ~ 195 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AK1 (AK1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 21635 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Adenylate Kinase 1 antibody (AK1) (AA 1-195) (ABIN393655) Immunofluorescence of monoclonal antibody to AK1 used as specificity and loading cont...
Immunohistochemistry (IHC) image for anti-Adenylate Kinase 1 antibody (AK1) (AA 1-195) (ABIN393655) anti-Adenylate Kinase 1 (AK1) (AA 1-195) antibody (Image 2)
Background publications Martins-de-Souza, Gattaz, Schmitt et al.: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, 2009 (PubMed).

Gloria-Bottini, Magrini, Pietropolli et al.: "Smoking and human reproduction: the effect of adenylate kinase genetic polymorphism." in: American journal of perinatology, Vol. 26, Issue 2, pp. 117-21, 2009 (PubMed).

Topalis, Alvarez, Barral et al.: "Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position." in: Nucleosides, nucleotides & nucleic acids, Vol. 27, Issue 4, pp. 319-31, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: , Vol. 3, pp. 89, 2007 (PubMed).