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Details for Product No. ABIN393659

Oxidative-Stress Responsive 1 (OXSR1) (Met16) antibody

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Antigen
Synonyms OSR1, 2210022N24Rik, 2810422B09Rik, AI462649, AW209236, Osr1, mKIAA1101, zgc:55494, zgc:77321
Epitope
»Alternatives Met16
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393659
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A8
Isotype IgG2a kappa
Specificity OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OXSR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58022 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Villa, Goebel, Rafiqi et al.: "Structural insights into the recognition of substrates and activators by the OSR1 kinase." in: EMBO reports, Vol. 8, Issue 9, pp. 839-45, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Richardson, Rafiqi, Karlsson et al.: "Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 675-84, 2008 (PubMed).

Villa, Deak, Alessi et al.: "Structure of the OSR1 kinase, a hypertension drug target." in: Proteins, Vol. 73, Issue 4, pp. 1082-7, 2008 (PubMed).

Lee, Cobb, Goldsmith: "Crystal structure of domain-swapped STE20 OSR1 kinase domain." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 2, pp. 304-13, 2009 (PubMed).

Alternatives for antigen "Oxidative-Stress Responsive 1 (OXSR1)", type "Antibodies"
Hosts (30), (29)
Reactivities (58), (24), (17), (13), (12), (12), (1)
Applications (47), (35), (18), (17), (10), (7), (6), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (8), (4), (2), (2), (1), (1), (1), (1), (1)
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