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Cyclin D2 antibody (CCND2) (AA 190-289)

Details for Product anti-CCND2 Antibody No. ABIN393662, Supplier: Log in to see
Antigen
  • si:ch211-240j22.2
  • ccnd2
  • CCND2
  • kiak0002
  • zgc:162280
  • LOC100224096
  • KIAK0002
  • BF642806
  • C86853
  • Vin-1
  • Vin1
  • cD2
  • 2600016F06Rik
  • AI256817
  • cyclin D2, b
  • cyclin D2
  • G1/S-specific cyclin-D2
  • cyclin D2, a
  • cyclin D1
  • ccnd2b
  • ccnd2-b
  • CCND2
  • ccnd2
  • ccnd2a
  • LOC100224096
  • CCND1
  • Ccnd2
  • ccnd2-a
Alternatives
anti-Human Cyclin D2 antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 190-289
20
19
15
13
10
10
9
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5
5
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3
3
3
3
2
1
1
1
Reactivity
Human
182
94
65
2
1
1
1
1
1
1
1
1
Host
Mouse
127
67
Clonality (Clone)
Monoclonal ()
Conjugate
This Cyclin D2 antibody is un-conjugated
5
5
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
158
54
35
33
30
21
15
13
13
12
6
4
4
3
2
1
1
1
1
Options
Supplier
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Immunogen CCND2 (AAH10958, 190 a.a. ~ 289 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B10
Isotype IgG1 kappa
Specificity CCND2 (AAH10958, 190 a.a. ~ 289 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCND2 (CCND2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33067 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cyclin D2 antibody (CCND2) (AA 190-289) (ABIN393662) Western Blot analysis of CCND2 expression in transfected 293T cell line by CCND2 mono...
Background publications Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Park, Chun, Bae, Park, Cheong, Lee, Kim, Shin: "CCND2 polymorphisms associated with clearance of HBV infection." in: Journal of human genetics, Vol. 55, Issue 7, pp. 416-20, 2010 (PubMed).

Kosmaczewska, Ciszak, Szteblich, Laba, Wojtowicz, Wolowiec, Frydecka: "Is cyclin D2 a marker of B-cLL cell activation?" in: Oncology research, Vol. 18, Issue 2-3, pp. 127-31, 2010 (PubMed).

Becker, Ghule, Lian, Stein, van Wijnen, Stein: "Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells." in: Journal of cellular physiology, Vol. 222, Issue 2, pp. 456-64, 2009 (PubMed).