Cyclin D2 (CCND2) (AA 190-289) antibody

Details for Product No. ABIN393662
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Antigen
Synonyms si:ch211-240j22.2, ccnd2, CCND2, kiak0002, zgc:162280, LOC100224096, KIAK0002, 2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2
Epitope
AA 190-289
(18), (11), (9), (9), (8), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(121), (60), (45), (1), (1), (1)
Host
Mouse
(78), (47)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(99), (38), (31), (23), (15), (14), (11), (10), (10), (8), (7), (6), (5), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393662
450.00 $
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Immunogen CCND2 (AAH10958, 190 a.a. ~ 289 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B10
Isotype IgG1 kappa
Specificity CCND2 (AAH10958, 190 a.a. ~ 289 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCND2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33067 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Cyclin D2 (CCND2) (AA 190-289) antibody Western Blot analysis of CCND2 expression in transfected 293T cell line by CCND2 monoclonal antibody (M01), clone 3B10. Lane 1: CCND2 transfected lysate(33.1 KDa). Lane 2: Non-transfected lysate.
Background publications Becker, Ghule, Lian et al.: "Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells." in: Journal of cellular physiology, Vol. 222, Issue 2, pp. 456-64, 2009 (PubMed).

Kosmaczewska, Ciszak, Szteblich et al.: "Is cyclin D2 a marker of B-cLL cell activation?" in: Oncology research, Vol. 18, Issue 2-3, pp. 127-31, 2010 (PubMed).

Park, Chun, Bae et al.: "CCND2 polymorphisms associated with clearance of HBV infection." in: Journal of human genetics, Vol. 55, Issue 7, pp. 416-20, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Validation Images
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