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VRK2 antibody (Vaccinia Related Kinase 2) (AA 260-360)

Details for Product anti-VRK2 Antibody No. ABIN393663, Supplier: Log in to see
Antigen
  • 2810003O05Rik
  • AI447698
Epitope
AA 260-360
17
15
5
4
3
2
2
1
1
Reactivity
Human
28
22
5
Host
Mouse
34
6
1
Clonality (Clone)
Monoclonal ()
Conjugate
This VRK2 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
38
26
3
2
1
Supplier
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Immunogen VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B10
Isotype IgG1 kappa
Specificity VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VRK2 (VRK2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58141 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-VRK2 antibody (Vaccinia Related Kinase 2) (AA 260-360) (ABIN393663) Immunofluorescence of monoclonal antibody to VRK2 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-VRK2 antibody (Vaccinia Related Kinase 2) (AA 260-360) (ABIN393663) anti-Vaccinia Related Kinase 2 (VRK2) (AA 260-360) antibody (Image 2)
Background publications Stefansson, Ophoff, Steinberg et al.: "Common variants conferring risk of schizophrenia." in: Nature, Vol. 460, Issue 7256, pp. 744-7, 2009 (PubMed).

Sanz-García, López-Sánchez, Lazo: "Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 11, pp. 2199-214, 2008 (PubMed).

Valbuena, Blanco, Vega et al.: "The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53." in: PLoS ONE, Vol. 3, Issue 7, pp. e2649, 2008 (PubMed).

Blanco, Sanz-García, Santos et al.: "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein." in: PLoS ONE, Vol. 3, Issue 2, pp. e1660, 2008 (PubMed).

Blanco, Santos, Lazo: "Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7273-83, 2007 (PubMed).