Vaccinia Related Kinase 2 (VRK2) antibody

Details for Product No. ABIN393663
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Synonyms 2810003O05Rik, AI447698
(21), (13), (5)
(18), (4)
Clonality (Clone)
Monoclonal ()
Immunofluorescence (IF), Western Blotting (WB)
(20), (11), (3), (3), (2), (2), (2)
Pubmed 5 references available
Catalog no. ABIN393663
Quantity 0.1 mg
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Immunogen VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B10
Isotype IgG1 kappa
Specificity VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VRK2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58141 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Vaccinia Related Kinase 2 (VRK2) antibody Immunofluorescence of monoclonal antibody to VRK2 on HeLa cell (antibody concentration 10 µg/mL). Western blot analysis of VRK2 over-expressed 293 cell line, cotransfected with VRK2 Validated Chimera RNAi used as specificity and loading control.
anti-Vaccinia Related Kinase 2 (VRK2) antibody (2) anti-Vaccinia Related Kinase 2 (VRK2) antibody (Image 2)
Background publications Blanco, Santos, Lazo: "Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7273-83, 2007 (PubMed).

Blanco, Sanz-García, Santos et al.: "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein." in: PLoS ONE, Vol. 3, Issue 2, pp. e1660, 2008 (PubMed).

Valbuena, Blanco, Vega et al.: "The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53." in: PLoS ONE, Vol. 3, Issue 7, pp. e2649, 2008 (PubMed).

Sanz-García, López-Sánchez, Lazo: "Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 11, pp. 2199-214, 2008 (PubMed).

Stefansson, Ophoff, Steinberg et al.: "Common variants conferring risk of schizophrenia." in: Nature, Vol. 460, Issue 7256, pp. 744-7, 2009 (PubMed).

Hosts (18), (4)
Reactivities (21), (13), (5)
Applications (20), (11), (3), (3), (2), (2), (2)
Epitopes (4), (2), (2), (1), (1), (1)
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