|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Vaccinia Related Kinase 2 (VRK2) antibody
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: vaccinia related kinase 2|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||VRK2 (AAH27854, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||58141 DA|
Background: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure|
|Restrictions||For Research Use only|
Blanco, Santos, Lazo: "Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7273-83, 2007 (PubMed).
Blanco, Sanz-García, Santos et al.: "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein." in: PLoS ONE, Vol. 3, Issue 2, pp. e1660, 2008 (PubMed).
Valbuena, Blanco, Vega et al.: "The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53." in: PLoS ONE, Vol. 3, Issue 7, pp. e2649, 2008 (PubMed).
Sanz-García, López-Sánchez, Lazo: "Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 11, pp. 2199-214, 2008 (PubMed).
Stefansson, Ophoff, Steinberg et al.: "Common variants conferring risk of schizophrenia." in: Nature, Vol. 460, Issue 7256, pp. 744-7, 2009 (PubMed).
|Hosts||Rabbit (11), Mouse (1)|
|Reactivities||Human (12), Mouse (Murine) (5), Rat (Rattus) (4), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (11), ELISA (10), Immunohistochemistry (IHC) (2), Dot Blot (DB) (1), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)|
|Epitopes||N-Term (2), AA 1-508 (1), Internal Region (1)|