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CDC25C antibody (Cell Division Cycle 25 Homolog C (S. Pombe)) (AA 21-130)

Details for Product anti-CDC25C Antibody No. ABIN393664, Supplier: Log in to see
Antigen
  • CDC25C
  • cdc25
  • xcdc25c
  • CDC25
  • PPP1R60
  • Cdc25
  • cdc25-3
  • xcdc25-3
Alternatives
anti-Human CDC25C antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 21-130
41
21
13
13
13
12
7
7
7
6
6
5
4
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
253
36
31
Host
Mouse
175
77
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CDC25C antibody is un-conjugated
6
6
6
3
3
3
3
3
3
3
3
3
3
3
3
1
1
Application
Western Blotting (WB)
180
83
82
44
33
29
28
15
12
5
4
3
1
1
1
1
Supplier
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Immunogen CDC25C (AAH19089, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B11
Isotype IgG1 kappa
Specificity CDC25C (AAH19089, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDC25C (CDC25C Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53365 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Pathways Cell Division Cycle
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CDC25C antibody (Cell Division Cycle 25 Homolog C (S. Pombe)) (AA 21-130) (ABIN393664) Western Blot analysis of CDC25C expression in transfected 293T cell line by CDC25C mo...
Immunohistochemistry (IHC) image for anti-CDC25C antibody (Cell Division Cycle 25 Homolog C (S. Pombe)) (AA 21-130) (ABIN393664) anti-Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C) (AA 21-130) antibody (Image 2)
Background publications Olson, Wang, Pankratz et al.: "Centrosome-related genes, genetic variation, and risk of breast cancer." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 221-8, 2010 (PubMed).

Wang, Trope, Flørenes et al.: "Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes." in: BMC cancer, Vol. 10, pp. 233, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Timofeev, Cizmecioglu, Settele et al.: "Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16978-90, 2010 (PubMed).

Bhattacharjee, Sheng, Ajees et al.: "Adventitious arsenate reductase activity of the catalytic domain of the human Cdc25B and Cdc25C phosphatases." in: Biochemistry, Vol. 49, Issue 4, pp. 802-9, 2010 (PubMed).