|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C) antibody
|Synonyms||Cdc25, CDC25C, CDC25, cdc25, xcdc25c|
Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||CDC25C (AAH19089, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: CDC25 cell division cycle 25C|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||CDC25C (AAH19089, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||53365 DA|
Background: This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure|
|Restrictions||For Research Use only|
Bhattacharjee, Sheng, Ajees et al.: "Adventitious arsenate reductase activity of the catalytic domain of the human Cdc25B and Cdc25C phosphatases." in: Biochemistry, Vol. 49, Issue 4, pp. 802-9, 2010 (PubMed).
Timofeev, Cizmecioglu, Settele et al.: "Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16978-90, 2010 (PubMed).
Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).
Wang, Trope, Flørenes et al.: "Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes." in: BMC cancer, Vol. 10, pp. 233, 2010 (PubMed).
Olson, Wang, Pankratz et al.: "Centrosome-related genes, genetic variation, and risk of breast cancer." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 221-8, 2010 (PubMed).