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LAT antibody (Linker For Activation of T Cells) (AA 1-234)

Details for Product anti-LAT Antibody No. ABIN393665, Supplier: Log in to see
Antigen
  • LAT
  • lat
  • LAT1
  • pp36
Alternatives
anti-Human LAT antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 1-234
27
17
14
11
9
6
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
183
83
74
1
1
1
1
Host
Mouse
130
48
13
2
Clonality (Clone)
Monoclonal ()
Conjugate
This LAT antibody is un-conjugated
6
6
5
5
5
4
3
3
3
3
3
3
3
1
1
Application
Western Blotting (WB)
132
63
33
29
26
15
10
9
6
2
2
2
2
2
1
1
Supplier
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Immunogen LAT (AAH11563, 1 a.a. ~ 234 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B11-1D5
Isotype IgG1 kappa
Specificity LAT (AAH11563, 1 a.a. ~ 234 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LAT (LAT Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LAT antibody (Linker For Activation of T Cells) (AA 1-234) (ABIN393665) LAT monoclonal antibody (M01), clone 3B11-1D5 Western Blot analysis of LAT expression...
Immunohistochemistry (IHC) image for anti-LAT antibody (Linker For Activation of T Cells) (AA 1-234) (ABIN393665) anti-Linker For Activation of T Cells (LAT) (AA 1-234) antibody (Image 2)
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Cruz-Orcutt, Houtman: "PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes." in: Molecular immunology, Vol. 46, Issue 11-12, pp. 2274-83, 2009 (PubMed).

Shen, Zhu, Lau et al.: "The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5596-604, 2009 (PubMed).

Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, 2009 (PubMed).