MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) antibody

Details for Product No. ABIN393666
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms EMK-1, EMK1, PAR-1, Par-1b, Par1b, AU024026, Emk, Par-1, mKIAA4207
Reactivity
Human
(70), (53), (50), (29), (26), (24), (12)
Host
Mouse
(62), (6), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(45), (43), (20), (19), (13), (9), (3), (1)
Pubmed 5 references available
Catalog no. ABIN393666
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen MARK2 (AAH08771, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B12
Isotype IgG2a kappa
Specificity MARK2 (AAH08771, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MARK2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87911 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) antibody Detection limit for recombinant GST tagged MARK2 is approximately 0.03 ng/mL as a capture antibody.
Background publications Motovska, Widimsky, Kvasnicka et al.: "High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 20, Issue 4, pp. 257-62, 2009 (PubMed).

Lin, Hou, Piwnica-Worms et al.: "The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 1215-21, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Yamashita, Suzuki, Satoh et al.: "The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 812-7, 2010 (PubMed).

Yoshimura, Terabayashi, Miki: "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation." in: Molecular and cellular biology, Vol. 30, Issue 9, pp. 2206-19, 2010 (PubMed).

Hosts (62), (6), (4)
Reactivities (70), (53), (50), (29), (26), (24), (12)
Applications (45), (43), (20), (19), (13), (9), (3), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (15), (7), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1)
back to top