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MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibody

Details for Product No. ABIN393666, Supplier: Log in to see
Antigen
  • AU024026
  • Emk
  • EMK-1
  • EMK1
  • mKIAA4207
  • PAR-1
  • Par-1
  • Par-1b
  • Par1b
Epitope
AA 401-500
27
10
8
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
93
37
32
6
4
1
Host
Mouse
75
14
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
ELISA, Western Blotting (WB)
75
63
36
26
11
5
4
3
2
Supplier
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Immunogen MARK2 (AAH08771, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B12
Isotype IgG2a kappa
Specificity MARK2 (AAH08771, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MARK2 (MARK2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87911 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibody (ABIN393666) Detection limit for recombinant GST tagged MARK2 is approximately 0.03 ng/mL as a cap...
Background publications Yoshimura, Terabayashi, Miki: "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation." in: Molecular and cellular biology, Vol. 30, Issue 9, pp. 2206-19, 2010 (PubMed).

Yamashita, Suzuki, Satoh, Ide, Amano, Masuda-Hirata, Hayashi, Hamada, Ogata, Ohno: "The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 812-7, 2010 (PubMed).

Sowa, Bennett, Gygi, Harper: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Lin, Hou, Piwnica-Worms, Shaw: "The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 1215-21, 2009 (PubMed).

Motovska, Widimsky, Kvasnicka, Petr, Bilkova, Hajkova, Marinov, Simek, Kala,: "High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 20, Issue 4, pp. 257-62, 2009 (PubMed).