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UHRF1 antibody (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1) (AA 694-794)

Details for Product anti-UHRF1 Antibody No. ABIN393667, Supplier: Log in to see
Antigen
  • AL022808
  • C6orf107
  • dJ349A12.1
  • fb97f09
  • hNP95
  • hUHRF1
  • ICBP90
  • NP95
  • Np95
  • RNF106
  • UHRF1
  • wu:fb97f09
  • zgc:63539
Epitope
AA 694-794
16
13
13
10
3
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
83
6
3
3
1
1
Host
Mouse
61
18
9
1
Clonality (Clone)
Monoclonal ()
Conjugate
This UHRF1 antibody is un-conjugated
3
3
3
3
3
3
Application
Immunofluorescence (IF), Western Blotting (WB)
77
42
29
14
11
10
7
7
6
1
1
Supplier
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Supplier Product No.
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Immunogen UHRF1 (NP_037414, 694 a.a. ~ 794 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B12
Isotype IgG1 kappa
Specificity UHRF1 (NP_037414, 694 a.a. ~ 794 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UHRF1 (UHRF1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 89814 DA
Gene ID 12406
NCBI Accession NP_037414
Research Area Ubiquitin-related antibodies, Signaling, Protein Modifications, Cell Cycle, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-UHRF1 antibody (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1) (AA 694-794) (ABIN393667) Immunofluorescence of monoclonal antibody to UHRF1 on MCF-7 cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-UHRF1 antibody (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1) (AA 694-794) (ABIN393667) anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 694-794) antibody (Image 2)
Background publications Hervouet, Lalier, Debien, Cheray, Geairon, Rogniaux, Loussouarn, Martin, Vallette, Cartron: "Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells." in: PLoS ONE, Vol. 5, Issue 6, pp. e11333, 2010 (PubMed).

Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Oguri, Kato, Yokoi, Yoshida, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Achour, Fuhrmann, Alhosin, Rondé, Chataigneau, Mousli, Schini-Kerth, Bronner: "UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity." in: Biochemical and biophysical research communications, Vol. 390, Issue 3, pp. 523-8, 2009 (PubMed).

Meilinger, Fellinger, Bultmann, Rothbauer, Bonapace, Klinkert, Spada, Leonhardt: "Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells." in: EMBO reports, Vol. 10, Issue 11, pp. 1259-64, 2009 (PubMed).