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Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) (AA 1-155) antibody

Details for Product No. ABIN393672, Supplier: Log in to see
Antigen
  • UBE2L3
  • E2-F1
  • L-UBC
  • UBCH7
  • UbcM4
  • C79827
  • Ubce7
  • ube2l3l
  • wu:fb38h03
Epitope
AA 1-155
42
20
17
3
2
2
2
2
2
1
1
1
Reactivity
Human
104
40
36
8
6
4
3
3
3
2
1
1
1
1
Host
Mouse
84
16
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
86
49
25
15
11
11
6
4
3
1
1
1
1
Supplier
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Immunogen UBE2L3 (AAH53368, 1 a.a. ~ 155 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B7
Isotype IgG2a kappa
Specificity UBE2L3 (AAH53368, 1 a.a. ~ 155 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UBE2L3 (UBE2L3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 17862 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) (AA 1-155) antibody (ABIN393672) Immunofluorescence of monoclonal antibody to UBE2L3 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) (AA 1-155) antibody (ABIN393672) anti-Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) (AA 1-155) antibody (Image 2)
Background publications Fransen, Visschedijk, van Sommeren et al.: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

Dubois, Trynka, Franke et al.: "Multiple common variants for celiac disease influencing immune gene expression...." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).

Purbeck, Eletr, Kuhlman: "Kinetics of the transfer of ubiquitin from UbcH7 to E6AP." in: Biochemistry, Vol. 49, Issue 7, pp. 1361-3, 2010 (PubMed).

Han, Zheng, Cui et al.: "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus...." in: Nature genetics, Vol. 41, Issue 11, pp. 1234-7, 2009 (PubMed).

Huang, de Jong, Wienk et al.: "E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity." in: Journal of molecular biology, Vol. 385, Issue 2, pp. 507-19, 2009 (PubMed).