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Cyclin K (CCNK) (AA 1-355) antibody

Details for Product No. ABIN393673
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Antigen
Synonyms CG15218, Dmel\\CG15218, fe49g08, si:dkey-60a16.2, wu:fe49g08, zgc:158372, MGC115029, cpr4, MGC145994, CPR4, AW123198, AW413594, CycK, cyclin-K
Epitope
AA 1-355
(7), (6), (2), (1), (1), (1)
Reactivity
Human
(24), (11), (11), (11), (11), (11), (11)
Host
Mouse
(21), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(15), (9), (9), (3), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393673
450.00 $
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Immunogen CCNK (AAH15935, 1 a.a. ~ 355 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B7-1B9
Isotype IgG1 kappa
Specificity CCNK (AAH15935, 1 a.a. ~ 355 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCNK
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41293 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Cyclin K (CCNK) (AA 1-355) antibody Western Blot analysis of CCNK expression in transfected 293T cell line by CCNK monoclonal antibody (M01), clone 3B7-1B9. Lane 1: CCNK transfected lysate(41 KDa). Lane 2: Non-transfected lysate. Western blot analysis of CCNK over-expressed 293 cell line, cotransfected with CCNK Validated Chimera RNAi used as specificity and loading control.
anti-Cyclin K (CCNK) (AA 1-355) antibody (2) anti-Cyclin K (CCNK) (AA 1-355) antibody (Image 2)
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Lim, Hao, Shaw et al.: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Baek, Brown, Birrane et al.: "Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9." in: Journal of molecular biology, Vol. 366, Issue 2, pp. 563-73, 2007 (PubMed).

Marsaud, Tchakarska, Andrieux et al.: "Cyclin K and cyclin D1b are oncogenic in myeloma cells." in: Molecular cancer, Vol. 9, pp. 103, 2010 (PubMed).

Validation Images
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