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BAMBI antibody (BMP and Activin Membrane-Bound Inhibitor Homolog) (AA 1-261)

Details for Product anti-BAMBI Antibody No. ABIN393678, Supplier: Log in to see
Antigen
  • NMA
  • nma
  • BAMBI
  • Zfnma
  • bambi
  • cb998
  • fc44c12
  • id:ibd5020
  • wu:fc44c12
  • wu:fe01e03
  • 2610003H06Rik
Epitope
AA 1-261
4
3
2
1
1
1
1
1
Reactivity
Human
40
23
22
14
2
2
2
2
Host
Mouse
35
6
Clonality (Clone)
Monoclonal ()
Conjugate
This BAMBI antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
20
15
11
5
4
2
2
1
Supplier
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Immunogen BAMBI (AAH19252, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C1-1D1
Isotype IgG1 kappa
Specificity BAMBI (AAH19252, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BAMBI (BAMBI Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 29108 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BAMBI antibody (BMP and Activin Membrane-Bound Inhibitor Homolog) (AA 1-261) (ABIN393678) BAMBI monoclonal antibody (M01), clone 3C1-1D1 Western Blot analysis of BAMBI express...
Background publications Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Pils, Wittinger, Petz et al.: "BAMBI is overexpressed in ovarian cancer and co-translocates with Smads into the nucleus upon TGF-beta treatment." in: Gynecologic oncology, Vol. 117, Issue 2, pp. 189-97, 2010 (PubMed).

Försti, Li, Wagner et al.: "Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression." in: Genes, chromosomes & cancer, Vol. 49, Issue 3, pp. 270-81, 2010 (PubMed).

Yan, Lin, Chen et al.: "Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30097-104, 2009 (PubMed).

Fritzmann, Morkel, Besser et al.: "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential." in: Gastroenterology, Vol. 137, Issue 1, pp. 165-75, 2009 (PubMed).