BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) antibody

Details for Product No. ABIN393678
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Antigen
Synonyms NMA, 2610003H06Rik, nma, BAMBI, Zfnma, bambi, cb998, fc44c12, id:ibd5020, wu:fc44c12, wu:fe01e03
Reactivity
Human
(23), (19), (19), (17), (17)
Host
Mouse
(20), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(16), (14), (8), (8), (5), (2), (2)
Pubmed 5 references available
Catalog no. ABIN393678
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen BAMBI (AAH19252, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C1-1D1
Isotype IgG1 kappa
Specificity BAMBI (AAH19252, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BAMBI
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 29108 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) antibody BAMBI monoclonal antibody (M01), clone 3C1-1D1 Western Blot analysis of BAMBI expression in K-562.
Background publications Fritzmann, Morkel, Besser et al.: "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential." in: Gastroenterology, Vol. 137, Issue 1, pp. 165-75, 2009 (PubMed).

Yan, Lin, Chen et al.: "Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30097-104, 2009 (PubMed).

Försti, Li, Wagner et al.: "Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression." in: Genes, chromosomes & cancer, Vol. 49, Issue 3, pp. 270-81, 2010 (PubMed).

Pils, Wittinger, Petz et al.: "BAMBI is overexpressed in ovarian cancer and co-translocates with Smads into the nucleus upon TGF-beta treatment." in: Gynecologic oncology, Vol. 117, Issue 2, pp. 189-97, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Hosts (20), (3)
Reactivities (23), (19), (19), (17), (17)
Applications (16), (14), (8), (8), (5), (2), (2)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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