BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) antibody

Antigen: BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI)

Synonyms: BAMBI, NMA, nma, MGC89501, Zfnma, bambi, cb998, fc44c12, id:ibd5020, wu:fc44c12, wu:fe01e03

Clonality: Monoclonal (3C1-1D1)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393678

Additional Information

Alternative name: BAMBI

Gene ID: 25805

Immunogen: BAMBI (AAH19252, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 3C1-1D1

Description: Other names: NMABMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: BAMBI (AAH19252, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 29108 DA

Comments:

Background: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Concentration: 1 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications

Restrictions: For Research Use only

Images

BAMBI monoclonal antibody (M01), clone 3C1-1D1 Western Blot analysis of BAMBI expression in K-562 ( Cat # L009V1 ).

Publications

Product: Fritzmann, Morkel, Besser et al.: "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential." in: Gastroenterology, Vol. 137, Issue 1, pp. 165-75, 2009 (PubMed).

Yan, Lin, Chen et al.: "Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30097-104, 2009 (PubMed).

Försti, Li, Wagner et al.: "Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression." in: Genes, chromosomes & cancer, Vol. 49, Issue 3, pp. 270-81, 2010 (PubMed).

Pils, Wittinger, Petz et al.: "BAMBI is overexpressed in ovarian cancer and co-translocates with Smads into the nucleus upon TGF-beta treatment." in: Gynecologic oncology, Vol. 117, Issue 2, pp. 189-97, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).