Ephrin A1 (EFNA1) antibody

Antigen: Ephrin A1 (EFNA1)

Synonyms: efna1, efna1a, elfa-a, xelf-a', EFNA1, efna1b, MGC130661, b61, efl1, ecklg, eplg1, lerk1, tnfaip4, MGC128366, B61, EFL1, ECKLG, EPLG1, LERK1, TNFAIP4, Efl1, Epl1, Eplg1, Lerk1, AI325262

Clonality: Monoclonal (3C6)

Host: Mouse

Reactivity: Human

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN393688

Additional Information

Alternative name: EFNA1

Gene ID: 1942

Immunogen: EFNA1 (AAH32698, 21 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG Mix kappa

Clone: 3C6

Description: Other names: B61, ECKLG, EFL1, EPLG1, LERK1, TNFAIP4 ephrin-A1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: EFNA1 (AAH32698, 21 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 23787 DA

Comments:

Background: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Yuan, Ge, Chen et al.: "Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients." in: Digestive diseases and sciences, Vol. 54, Issue 11, pp. 2410-7, 2009 (PubMed).

Himanen, Goldgur, Miao et al.: "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex." in: EMBO reports, Vol. 10, Issue 7, pp. 722-8, 2009 (PubMed).

Miao, Li, Mukherjee et al.: "EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt." in: Cancer cell, Vol. 16, Issue 1, pp. 9-20, 2009 (PubMed).

Cui, Lee, Yu et al.: "EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 4, pp. 940-9, 2009 (PubMed).

Zhang, Zeng, Briggs et al.: "A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1." in: Oncogene, Vol. 29, Issue 17, pp. 2467-76, 2010 (PubMed).