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LIM Domain Binding 3 Protein antibody (LIM Domain Binding 3) (AA 1-284)

Details for Product anti-LDB3 Antibody No. ABIN393691, Supplier: Log in to see
Antigen
  • ldb3l
  • zgc:55814
  • wu:fi31d08
  • ldb3
  • MGC52706
  • MGC75668
  • LDB3
  • CMD1C
  • CYPHER
  • LDB3Z1
  • LDB3Z4
  • LVNC3
  • MFM4
  • ORACLE
  • PDLIM6
  • ZASP
  • AW742271
  • RGD1564875
Epitope
AA 1-284
22
16
12
5
5
3
2
2
1
Reactivity
Human
59
13
10
3
3
2
1
1
Host
Mouse
33
18
8
Clonality (Clone)
Monoclonal ()
Conjugate
This LIM Domain Binding 3 Protein antibody is un-conjugated
3
3
3
3
3
3
1
Application
Western Blotting (WB)
53
39
18
5
3
1
1
Supplier
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Immunogen LDB3 (AAH10929, 1 a.a. ~ 284 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C8
Isotype IgG2b kappa
Specificity LDB3 (AAH10929, 1 a.a. ~ 284 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name LDB3 (LDB3 Antibody Abstract)
Background This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified, all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
Synonyms: CYPHER, KIAA01613, KIAA0613, ORACLE, PDLIM6, ZASP LIM domain binding 3
Molecular Weight NONE?! DA
Gene ID 11155
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified, all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LIM Domain Binding 3 Protein antibody (LIM Domain Binding 3) (AA 1-284) (ABIN393691) Western blot analysis of LDB3 over-expressed 293 cell line, cotransfected with LDB3 V...
Immunohistochemistry (IHC) image for anti-LIM Domain Binding 3 Protein antibody (LIM Domain Binding 3) (AA 1-284) (ABIN393691) anti-LIM Domain Binding 3 (LDB3) (AA 1-284) antibody (Image 2)
Background publications Zimmerman, Cox, Lakdawala et al.: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).

Rampersaud, Kinnamon, Hamilton et al.: "Common susceptibility variants examined for association with dilated cardiomyopathy." in: Annals of human genetics, Vol. 74, Issue 2, pp. 110-6, 2010 (PubMed).

Vihola, Bachinski, Sirito et al.: "Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2." in: Acta neuropathologica, Vol. 119, Issue 4, pp. 465-79, 2010 (PubMed).

Aurino, Piluso, Saccone et al.: "Candidate-gene testing for orphan limb-girdle muscular dystrophies." in: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases, Vol. 27, pp. 90-7, 2009 (PubMed).

Arimura, Inagaki, Hayashi et al.: "Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy." in: Cardiovascular research, Vol. 83, Issue 1, pp. 80-8, 2009 (PubMed).