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ATRX antibody (helicase 2, X-linked) (AA 2311-2411)

Details for Product anti-ATRX Antibody No. ABIN393693, Supplier: Login to see
Antigen
  • ATR2
  • JMS
  • MRXHF1
  • RAD54
  • RAD54L
  • SFM1
  • SHS
  • XH2
  • XNP
  • ZNF-HX
  • Xnp
  • 4833408C14Rik
  • AI447451
  • DXHXS6677E
  • HP1-BP38
  • Hp1bp2
  • Hp1bp38
  • MRXS3
  • Rad54
Epitope
AA 2311-2411
27
14
6
4
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
68
13
2
2
1
1
1
Host
Mouse
49
17
2
Clonality (Clone)
Monoclonal ()
Conjugate
This ATRX antibody is un-conjugated
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
52
45
17
15
9
6
6
2
1
1
1
1
1
1
1
Supplier
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Immunogen ATRX (NP_000480, 2311 a.a. ~ 2411 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C9
Isotype IgG1 kappa
Specificity ATRX (NP_000480, 2311 a.a. ~ 2411 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ATRX (ATRX Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 282566 DA
Gene ID 12406
NCBI Accession NP_000480
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ATRX antibody (helicase 2, X-linked) (AA 2311-2411) (ABIN393693) Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/mL as a captu...
Background publications Kernohan, Jiang, Tremblay et al.: "ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain." in: Developmental cell, Vol. 18, Issue 2, pp. 191-202, 2010 (PubMed).

Lukashchuk, Everett: "Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx." in: Journal of virology, Vol. 84, Issue 8, pp. 4026-40, 2010 (PubMed).

Wong, McGhie, Sim et al.: "ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells." in: Genome research, Vol. 20, Issue 3, pp. 351-60, 2010 (PubMed).

Breuer, Skoumal, Horkay et al.: "Strong relationship between NT-proXNP levels and cardiac output following cardiac surgery in neonates and infants." in: Acta anaesthesiologica Scandinavica, Vol. 54, Issue 4, pp. 502-9, 2010 (PubMed).

Cohn, Pagon, Hudgins et al.: "Partial ATRX gene duplication causes ATR-X syndrome." in: American journal of medical genetics. Part A, Vol. 149A, Issue 10, pp. 2317-20, 2009 (PubMed).