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Ring Finger Protein 139 (RNF139) (AA 565-665) antibody

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Synonyms RNF139, DKFZp469C1333, HRCA1, RCA1, TRC8, 4930555P18Rik
AA 565-665
(16), (3), (3), (3), (1), (1)
(40), (19), (18), (4), (1), (1), (1), (1), (1)
(20), (17), (5)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(30), (24), (11), (10), (7), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen RNF139 (NP_009149, 565 a.a. ~ 665 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D10
Isotype IgG1 kappa
Specificity RNF139 (NP_009149, 565 a.a. ~ 665 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RNF139 (RNF139 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 75994 DA
Gene ID 12406
NCBI Accession NP_009149
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure, Cancer
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ring Finger Protein 139 (RNF139) (AA 565-665) antibody (ABIN393698) RNF139 monoclonal antibody (M01), clone 3D10 Western Blot analysis of RNF139 expressi...
Immunohistochemistry (IHC) image for anti-Ring Finger Protein 139 (RNF139) (AA 565-665) antibody (ABIN393698) anti-Ring Finger Protein 139 (RNF139) (AA 565-665) antibody (Image 2)
Background publications Lee, Brauweiler, Rudolph et al.: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, 2010 (PubMed).

Stagg, Thomas, van den Boomen et al.: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, 2009 (PubMed).

Irisawa, Inoue, Ozawa et al.: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, 2009 (PubMed).

Poland, Azim, Folsom et al.: "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma." in: Genes, chromosomes & cancer, Vol. 46, Issue 9, pp. 805-12, 2007 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Catalog No. ABIN393698
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