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Ring Finger Protein 139 (RNF139) antibody

Details for Product No. ABIN393698
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Antigen
Synonyms HRCA1, RCA1, TRC8, 4930555P18Rik, RNF139, DKFZp469C1333
Reactivity
Human
(29), (15), (13), (13), (13), (12), (12), (1)
Host
Mouse
(16), (10), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(22), (19), (10), (8), (8)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN393698
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen RNF139 (NP_009149, 565 a.a. ~ 665 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D10
Isotype IgG1 kappa
Specificity RNF139 (NP_009149, 565 a.a. ~ 665 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RNF139
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 75994 DA
Gene ID 12406
UniProt NP_009149
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure, Cancer
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ring Finger Protein 139 (RNF139) antibody RNF139 monoclonal antibody (M01), clone 3D10 Western Blot analysis of RNF139 expression in HepG2 on formalin-fixed paraffin-embedded human tonsil (antibody concentration 3 µg/mL).
anti-Ring Finger Protein 139 (RNF139) antibody (2) anti-Ring Finger Protein 139 (RNF139) antibody (Image 2)
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Poland, Azim, Folsom et al.: "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma." in: Genes, chromosomes & cancer, Vol. 46, Issue 9, pp. 805-12, 2007 (PubMed).

Irisawa, Inoue, Ozawa et al.: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, 2009 (PubMed).

Stagg, Thomas, van den Boomen et al.: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, 2009 (PubMed).

Lee, Brauweiler, Rudolph et al.: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN393698
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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