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Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody

Details for Product No. ABIN393700, Supplier: Login to see
Antigen
  • MLTK
  • RGD1561394
  • AZK
  • MLK7
  • MLT
  • MRK
  • mlklak
  • pk
  • AV006891
  • B230120H23Rik
  • MLTKalpha
  • MLTKbeta
Epitope
AA 1-456
10
10
9
7
7
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
78
28
15
Host
Mouse
61
17
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF)
60
46
20
18
12
11
4
2
1
1
1
Supplier
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Immunogen ZAK (AAH01401, 1 a.a. ~ 456 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D11
Isotype IgG1 kappa
Specificity ZAK (AAH01401, 1 a.a. ~ 456 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZAK (ZAK Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 91181 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Cell Structure
Pathways
Comment

Background: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody (ABIN393700) Immunofluorescence of to ZAK on HeLa cell . Detection limit for recombinant GST tagge...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody (ABIN393700) anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody (Image 2)
Background publications Wang, Han, Ye et al.: "Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRK-beta." in: Electrophoresis, Vol. 31, Issue 8, pp. 1283-93, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Yang, Lee, Hung et al.: "ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner." in: Cancer science, Vol. 101, Issue 6, pp. 1374-81, 2010 (PubMed).

Jandhyala, Ahluwalia, Obrig et al.: "ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression." in: Cellular microbiology, Vol. 10, Issue 7, pp. 1468-77, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).