Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody

Details for Product No. ABIN393700
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Antigen
Synonyms MLTK, RGD1561394, AZK, MLK7, MLT, MRK, mlklak, pk, AV006891, B230120H23Rik, MLTKalpha, MLTKbeta
Epitope
AA 1-456
(7), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(59), (25), (13), (12), (12), (12), (12)
Host
Mouse
(43), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF)
(48), (39), (14), (11), (10), (10), (8), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393700
450.00 $
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Immunogen ZAK (AAH01401, 1 a.a. ~ 456 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D11
Isotype IgG1 kappa
Specificity ZAK (AAH01401, 1 a.a. ~ 456 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZAK
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 91181 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Cell Structure
Comment

Background: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody Immunofluorescence of to ZAK on HeLa cell . Detection limit for recombinant GST tagged ZAK is approximately 0.3 ng/mL as a capture antibody.
anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody (2) anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) (AA 1-456) antibody (Image 2)
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Jandhyala, Ahluwalia, Obrig et al.: "ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression." in: Cellular microbiology, Vol. 10, Issue 7, pp. 1468-77, 2008 (PubMed).

Yang, Lee, Hung et al.: "ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner." in: Cancer science, Vol. 101, Issue 6, pp. 1374-81, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Wang, Han, Ye et al.: "Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRK-beta." in: Electrophoresis, Vol. 31, Issue 8, pp. 1283-93, 2010 (PubMed).

Validation Images
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