anti-GADD45A antibody (Growth Arrest and DNA-Damage-Inducible, alpha) (AA 76-165)

Details for Product anti-GADD45A Antibody No. ABIN393701
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Synonyms MGC53491, gadd45a, zgc:91795, GADD45A, ddit1, gadd45, GADD45, AA545191, Ddit1, DDIT1, Gadd45
AA 76-165
(12), (11), (10), (6), (3), (2), (1), (1), (1), (1), (1)
(72), (24), (21)
(58), (14)
Clonality (Clone)
Monoclonal ()
This GADD45A antibody is un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(55), (18), (12), (10), (4), (4), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen GADD45A (AAH11757, 76 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D12
Isotype IgG1 kappa
Specificity GADD45A (AAH11757, 76 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GADD45A (GADD45A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18336 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Pathways p53 Signaling, Cell Division Cycle
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Sánchez, Pantoja-Uceda, Prieto et al.: "Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22196-201, 2010 (PubMed).

van Roon, van Puijenbroek, Middeldorp et al.: "Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?" in: BMC cancer, Vol. 10, pp. 180, 2010 (PubMed).

Li, Zhao, Yin et al.: "Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells." in: Arthritis and rheumatism, Vol. 62, Issue 5, pp. 1438-47, 2010 (PubMed).

Young, Hopkins, Hay et al.: "A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers." in: Postgraduate medical journal, Vol. 85, Issue 1008, pp. 515-24, 2009 (PubMed).

Yu, Di, Li et al.: "Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations." in: Breast cancer research and treatment, Vol. 121, Issue 1, pp. 157-67, 2010 (PubMed).

Catalog No. ABIN393701
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