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GADD45A antibody (Growth Arrest and DNA-Damage-Inducible, alpha) (AA 76-165)

Details for Product anti-GADD45A Antibody No. ABIN393701, Supplier: Log in to see
Antigen
  • MGC53491
  • zgc:91795
  • gadd45a
  • GADD45A
  • ddit1
  • gadd45
  • GADD45
  • AA545191
  • Ddit1
  • DDIT1
  • Gadd45
Alternatives
anti-Human GADD45A antibody for Enzyme Immunoassay
Epitope
AA 76-165
14
13
10
7
3
2
2
2
1
1
1
1
Reactivity
Human
76
28
27
Host
Mouse
65
12
Clonality (Clone)
Monoclonal ()
Conjugate
This GADD45A antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
55
18
11
11
6
4
2
1
Supplier
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Immunogen GADD45A (AAH11757, 76 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D12
Isotype IgG1 kappa
Specificity GADD45A (AAH11757, 76 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GADD45A (GADD45A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18336 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Pathways p53 Signaling, Cell Division Cycle
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Sánchez, Pantoja-Uceda, Prieto et al.: "Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22196-201, 2010 (PubMed).

van Roon, van Puijenbroek, Middeldorp et al.: "Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?" in: BMC cancer, Vol. 10, pp. 180, 2010 (PubMed).

Li, Zhao, Yin et al.: "Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells." in: Arthritis and rheumatism, Vol. 62, Issue 5, pp. 1438-47, 2010 (PubMed).

Young, Hopkins, Hay et al.: "A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers." in: Postgraduate medical journal, Vol. 85, Issue 1008, pp. 515-24, 2009 (PubMed).

Yu, Di, Li et al.: "Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations." in: Breast cancer research and treatment, Vol. 121, Issue 1, pp. 157-67, 2010 (PubMed).