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Interleukin 23 Receptor (IL23R) (AA 553-629) antibody

Details for Product No. ABIN393707, Supplier: Log in to see
Antigen
  • IL-23R
  • il-23r
  • IL23R
Epitope
AA 553-629
17
15
13
8
5
4
3
3
3
2
2
2
1
1
1
1
Reactivity
Human
93
30
24
20
Host
Mouse
53
37
5
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
5
5
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
79
31
31
18
11
9
5
2
2
1
1
1
1
Supplier
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Immunogen IL23R (NP_653302, 553 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D7
Isotype IgG2a kappa
Specificity IL23R (NP_653302, 553 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL23R (IL23R Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 71706 DA
Gene ID 12406
NCBI Accession NP_653302
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Interleukin 23 Receptor (IL23R) (AA 553-629) antibody (ABIN393707) IL23R monoclonal antibody (M01), clone 3D7 Western Blot analysis of IL23R expression ...
Immunohistochemistry (IHC) image for anti-Interleukin 23 Receptor (IL23R) (AA 553-629) antibody (ABIN393707) anti-Interleukin 23 Receptor (IL23R) (AA 553-629) antibody (Image 2)
Background publications Elmaagacli, Steckel, Ditschkowski, Hegerfeldt, Ottinger, Trenschel, Koldehoff, Beelen: "Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors." in: Bone marrow transplantation, Vol. 46, Issue 5, pp. 702-8, 2011

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Mizuki, Meguro, Ota, Ohno, Shiota, Kawagoe, Ito, Kera, Okada, Yatsu, Song, Lee, Kitaichi, Namba, Horie, Takeno, Sugita, Mochizuki, Bahram, Ishigatsubo, Inoko: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010

Remmers, Cosan, Kirino, Ombrello, Abaci, Satorius, Le, Yang, Korman, Cakiris, Aglar, Emrence, Azakli, Ustek, Tugal-Tutkun, Akman-Demir, Chen, Amos, Dizon, Kose, Azizlerli, Erer, Brand, Kaklamani, Kaklamanis, Ben-Chetrit, Stanford, Fortune, Ghabra, Ollier,: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010

Chen, Lu, Zhang, Ding, Ren, Hua, Zhou, Deng, Jin, Hu, Xu, Shen: "A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population." in: Molecular carcinogenesis, Vol. 49, Issue 10, pp. 862-8, 2010