Interleukin 23 Receptor (IL23R) (AA 553-629) antibody

Details for Product No. ABIN393707
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Antigen
Synonyms IL-23R, IL23R, il-23r
Epitope
AA 553-629
(8), (7), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(47), (19), (17), (12)
Host
Mouse
(33), (12), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(35), (20), (10), (7), (7), (3), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393707
450.00 $
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Immunogen IL23R (NP_653302, 553 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D7
Isotype IgG2a kappa
Specificity IL23R (NP_653302, 553 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL23R
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 71706 DA
Gene ID 12406
NCBI Accession NP_653302
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Interleukin 23 Receptor (IL23R) (AA 553-629) antibody IL23R monoclonal antibody (M01), clone 3D7 Western Blot analysis of IL23R expression in A-431. Detection limit for recombinant GST tagged IL23R is approximately 0.1 ng/mL as a capture antibody.
anti-Interleukin 23 Receptor (IL23R) (AA 553-629) antibody (2) anti-Interleukin 23 Receptor (IL23R) (AA 553-629) antibody (Image 2)
Background publications Chen, Lu, Zhang et al.: "A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population." in: Molecular carcinogenesis, Vol. 49, Issue 10, pp. 862-8, 2010 (PubMed).

Remmers, Cosan, Kirino et al.: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010 (PubMed).

Mizuki, Meguro, Ota et al.: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010 (PubMed).

Elmaagacli, Steckel, Ditschkowski et al.: "Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors." in: Bone marrow transplantation, Vol. 46, Issue 5, pp. 702-8, 2011 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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