|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Ubiquitin-Conjugating Enzyme E2A (ube2a) antibody
|Synonyms||UBC2, HHR6A, RAD6A, HR6A, Mhr6a, UBE2A, BHR6A, MGC127256, MGC68540, ubc2, hhr6a, rad6a, MGC69378, MGC64109, wu:fa01h11, si:bz46j2.4, mp:zf637-2-000771|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||UBE2A (AAH10175, 1 a.a. ~ 153 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: HHR6A, RAD6A, UBC2 ubiquitin-conjugating enzyme E2A (RAD6 homolog)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||UBE2A (AAH10175, 1 a.a. ~ 153 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||17315 DA|
Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Ubiquitin-related antibodies, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Suzumori, Burns, Yan et al.: "RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 550-5, 2003 (PubMed).
Lyakhovich, Shekhar: "Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response." in: Molecular and cellular biology, Vol. 23, Issue 7, pp. 2463-75, 2003 (PubMed).
Kunapuli, Somerville, Still et al.: "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins." in: Oncogene, Vol. 22, Issue 22, pp. 3417-23, 2003 (PubMed).
Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).
Nascimento, Otto, de Brouwer et al.: "UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome." in: American journal of human genetics, Vol. 79, Issue 3, pp. 549-55, 2006 (PubMed).
|Hosts||Rabbit (9), Mouse (3)|
|Reactivities||Human (11), Mouse (Murine) (3), Rat (Rattus) (3)|
|Applications||Western Blotting (WB) (9), ELISA (5), Immunofluorescence (IF) (4), Immunohistochemistry (IHC) (4), Dot Blot (Dot) (1), Flow Cytometry (FACS) (1), Immunocytochemistry (ICC) (1)|
|Epitopes||N-Term (2), AA 10-50 (1), AA 100-150 (1)|