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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 1-733) antibody

Details for Product No. ABIN393709, Supplier: Login to see
Antigen
  • AI314015
  • Ku80
  • Ku86
  • Kup80
  • KARP-1
  • KARP1
  • KU80
  • KUB2
  • NFIV
  • xrcc5-a
  • XRCC5
Alternatives
anti-Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) antibody for Immunocytochemistry
Epitope
AA 1-733
39
35
11
9
8
8
7
5
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
236
41
28
16
6
2
1
1
1
Host
Mouse
145
70
25
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
194
84
70
62
58
34
32
31
11
7
5
3
3
1
1
1
1
1
1
Supplier
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Immunogen XRCC5 (AAH19027, 1 a.a. ~ 733 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D8
Isotype IgG1 kappa
Specificity XRCC5 (AAH19027, 1 a.a. ~ 733 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name XRCC5 (XRCC5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82705 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Pathways DNA Damage Repair
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 1-733) antibody (ABIN393709) XRCC5 monoclonal antibody (M02), clone 3D8 Western Blot analysis of XRCC5 expression ...
Immunohistochemistry (IHC) image for anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 1-733) antibody (ABIN393709) anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 1-733) antibody (Image 2)
Background publications Gomes, Silva, Azevedo et al.: "The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk." in: Oncology reports, Vol. 24, Issue 4, pp. 1079-85, 2010 (PubMed).

Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).

Liu, Shete, Wang et al.: "Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk." in: Carcinogenesis, Vol. 31, Issue 10, pp. 1762-9, 2010 (PubMed).

Briggs, Goldstein, McCauley et al.: "Variation within DNA repair pathway genes and risk of multiple sclerosis." in: American journal of epidemiology, Vol. 172, Issue 2, pp. 217-24, 2010 (PubMed).

Monsees, Kraft, Chanock et al.: "Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 207-14, 2010 (PubMed).