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F-Box Protein 6 (FBXO6) (AA 1-294) antibody

Details for Product No. ABIN393713, Supplier: Log in to see
Antigen
  • FBXO6
  • FBG2
  • FBS2
  • FBX6
  • Fbx6b
  • AA408845
  • Fbs2
  • Fbxo6b
  • Fbg2
  • F17L21.13
  • F17L21_13
Epitope
AA 1-294
7
5
5
4
4
1
1
Reactivity
Human
35
9
9
Host
Mouse
17
14
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
Application
Western Blotting (WB)
23
21
4
2
1
Supplier
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Immunogen FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F10
Isotype IgG1 kappa
Specificity FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBXO6 (FBXO6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33933 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-F-Box Protein 6 (FBXO6) (AA 1-294) antibody (ABIN393713) Western Blot analysis of FBXO6 expression in transfected 293T cell line by FBXO6 mono...
Background publications Zhang, Brognard, Coughlin et al.: "The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress." in: Molecular cell, Vol. 35, Issue 4, pp. 442-53, 2009 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Yoshida, Tokunaga, Chiba et al.: "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43877-84, 2003 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).