F-Box Protein 6 (FBXO6) (AA 1-294) antibody

Details for Product No. ABIN393713
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Antigen
Synonyms FBXO6, FBG2, FBS2, FBX6, Fbx6b, AA408845, Fbs2, Fbxo6b, Fbg2, F17L21.13, F17L21_13
Epitope
AA 1-294
(4), (3), (2), (1), (1)
Reactivity
Human
(32), (17), (17), (11), (11), (11)
Host
Mouse
(25), (5), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(18), (11), (9), (4), (3), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393713
450.00 $
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Immunogen FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F10
Isotype IgG1 kappa
Specificity FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBXO6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33933 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-F-Box Protein 6 (FBXO6) (AA 1-294) antibody Western Blot analysis of FBXO6 expression in transfected 293T cell line by FBXO6 monoclonal antibody (M01), clone 3F10. Lane 1: FBXO6 transfected lysate(33.933 KDa). Lane 2: Non-transfected lysate.
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Yoshida, Tokunaga, Chiba et al.: "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43877-84, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Zhang, Brognard, Coughlin et al.: "The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress." in: Molecular cell, Vol. 35, Issue 4, pp. 442-53, 2009 (PubMed).

Validation Images
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