F-Box Protein 6 (FBXO6) antibody

Details for Product No. ABIN393713
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Antigen
Synonyms FBG2, FBS2, FBX6, Fbx6b, Fbs2, Fbxo6b, AA408845, Fbg2, FBXO6, F17L21.13, F17L21_13
Reactivity
Human
(32), (17), (17), (11), (11), (11)
Host
Mouse
(24), (5), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(18), (12), (9), (4), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN393713
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F10
Isotype IgG1 kappa
Specificity FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBXO6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33933 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-F-Box Protein 6 (FBXO6) antibody Western Blot analysis of FBXO6 expression in transfected 293T cell line by FBXO6 monoclonal antibody (M01), clone 3F10. Lane 1: FBXO6 transfected lysate(33.933 KDa). Lane 2: Non-transfected lysate.
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Yoshida, Tokunaga, Chiba et al.: "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43877-84, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1...." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Zhang, Brognard, Coughlin et al.: "The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress." in: Molecular cell, Vol. 35, Issue 4, pp. 442-53, 2009 (PubMed).

Hosts (24), (5), (3)
Reactivities (32), (17), (17), (11), (11), (11)
Applications (18), (12), (9), (4), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2)
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