Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) antibody

Antigen: Ubiquitin Specific Peptidase 17-Like 2 (USP17L2)

Synonyms: DUB3, Dub6, Gm6596, EG625530

Clonality: Monoclonal (3G12)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393724

Additional Information

Alternative name: DUB3

Gene ID: 377630

UniProt: NP_958804

Immunogen: DUB3 (NP_958804, 431 a.a. ~ 531 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 3G12

Description: Other names: deubiquitinating enzyme 3

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: DUB3 (NP_958804, 431 a.a. ~ 531 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 59711 DA

Comments:

Background: DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for Background: information.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Ubiquitin-related antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged DUB3 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Burrows, McGrattan, Rascle et al.: "DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 13993-4000, 2004 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Alkan, Kidd, Marques-Bonet et al.: "Personalized copy number and segmental duplication maps using next-generation sequencing." in: Nature genetics, Vol. 41, Issue 10, pp. 1061-7, 2009 (PubMed).

Pereg, Liu, ORourke et al.: "Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A." in: Nature cell biology, Vol. 12, Issue 4, pp. 400-6, 2010 (PubMed).