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F-Box and Leucine-Rich Repeat Protein 18 (FBXL18) (AA 1-111) antibody

Details for Product No. ABIN393741, Supplier: Login to see
Antigen
  • Fbl18
  • AI427077
  • B130019G13Rik
  • C330021B20Rik
  • FBXL18
  • zgc:114102
Epitope
AA 1-111
3
2
2
2
1
Reactivity
Human
26
4
4
Host
Mouse
20
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
Application
Western Blotting (WB)
18
17
6
1
1
Supplier
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Immunogen FBXL18 (NP_079239, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3H5
Isotype IgG1 kappa
Specificity FBXL18 (NP_079239, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBXL18 (FBXL18 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 88341 DA
Gene ID 12406
NCBI Accession NP_079239
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-F-Box and Leucine-Rich Repeat Protein 18 (FBXL18) (AA 1-111) antibody (ABIN393741) FBXL18 monoclonal antibody (M01), clone 3H5 Western Blot analysis of FBXL18 expressio...
Immunohistochemistry (IHC) image for anti-F-Box and Leucine-Rich Repeat Protein 18 (FBXL18) (AA 1-111) antibody (ABIN393741) anti-F-Box and Leucine-Rich Repeat Protein 18 (FBXL18) (AA 1-111) antibody (Image 2)
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Jin, Cardozo, Lovering et al.: "Systematic analysis and nomenclature of mammalian F-box proteins." in: Genes & development, Vol. 18, Issue 21, pp. 2573-80, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).