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Retinoblastoma Binding Protein 4 (RBBP4) antibody

Details for Product No. ABIN393749
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Antigen
Synonyms
NURF55, RBAP48, mRbAp48, RBBP-4, nurf55, rbap48, rbbp4, xrbbp4, 154659_at, 55, CAF-1, CAF1, CAF1-55, CAF1p55, CG4236, Caf-1, Caf1/p55, Caf1p55, Dmel\\CG4236, MSI1/RbAp48/CAC3/LIN-53, NURF, NURF-55, Nu ... show more
NURF55, RBAP48, mRbAp48, RBBP-4, nurf55, rbap48, rbbp4, xrbbp4, 154659_at, 55, CAF-1, CAF1, CAF1-55, CAF1p55, CG4236, Caf-1, Caf1/p55, Caf1p55, Dmel\\CG4236, MSI1/RbAp48/CAC3/LIN-53, NURF, NURF-55, Nurf, Nurf 55, Nurf-55, Nurf55, P55, RbAp48, S(ls)3, caf-1, caf1, caf1 p55, d-CAF1, dCAF-1, dCAF-1 p55, dNURF, p55, p55 CAF1, p55/NURF-55, p55CAF1, RBBP4, rbb4-2, zgc:55349, zgc:77854, wu:fb33a09, wu:fb40e10 show less
Reactivity
Human
(52), (24), (23), (12), (2), (2)
Host
Mouse
(38), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(43), (18), (13), (13), (13), (10), (10), (5), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393749
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen RBBP4 (NP_005601, 316 a.a. ~ 426 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A5
Isotype IgG2a kappa
Specificity RBBP4 (NP_005601, 316 a.a. ~ 426 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBBP4
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 47656 DA
Gene ID 12406
UniProt NP_005601
Research Area Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Retinoblastoma Binding Protein 4 (RBBP4) antibody Immunofluorescence of monoclonal antibody to RBBP4 on HeLa cell (antibody concentration 10 µg/mL). RBBP4 monoclonal antibody (M02), clone 4A5 Western Blot analysis of RBBP4 expression in HeLa NE.
anti-Retinoblastoma Binding Protein 4 (RBBP4) antibody (2) anti-Retinoblastoma Binding Protein 4 (RBBP4) antibody (Image 2)
Background publications Ishimaru, Arakaki, Yoshida et al.: "Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy." in: The Journal of experimental medicine, Vol. 205, Issue 12, pp. 2915-27, 2008 (PubMed).

Li, Zhang, Yu et al.: "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis." in: The EMBO journal, Vol. 28, Issue 18, pp. 2763-76, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Li, Margueron, Ku et al.: "Jarid2 and PRC2, partners in regulating gene expression." in: Genes & development, Vol. 24, Issue 4, pp. 368-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hosts (38), (16)
Reactivities (52), (24), (23), (12), (2), (2)
Applications (43), (18), (13), (13), (13), (10), (10), (5), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (3), (3), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN393749
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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