Retinoblastoma Binding Protein 4 (RBBP4) antibody

Antigen: Retinoblastoma Binding Protein 4 (RBBP4)

Synonyms: NURF55, RBAP48, 154659_at, 55, caf-1, Caf-1, CAF-1, caf1, CAF1, caf1 p55, Caf1/p55, Caf1p55, CAF1p55, CG4236, d-CAF1, dCAF-1, dCAF-1 p55, DmelCG4236, dNURF, MSI1/RbAp48/CAC3/LIN-53, NURF, Nurf-55, NURF-55, Nurf55, p55, P55, p55/NURF-55, p55CAF1, RbAp48, nurf55, rbap48, MGC79922, mRbAp48, RBBP4, rbb4-2, zgc:55349, zgc:77854, wu:fb33a09, wu:fb40e10, MGC128413, RBBP-4, DKFZp469A0122

Clonality: Monoclonal (4A5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393749

Additional Information

Alternative name: RBBP4

Gene ID: 5928

UniProt: NP_005601

Immunogen: RBBP4 (NP_005601, 316 a.a. ~ 426 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 4A5

Description: Other names: RBAP48 retinoblastoma binding protein 4

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: RBBP4 (NP_005601, 316 a.a. ~ 426 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 47656 DA

Comments:

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

Synonyms: NURF55, RBAP48, 154659_at, 55, caf-1, Caf-1, CAF-1, caf1, CAF1, caf1 p55, Caf1/p55, Caf1p55, CAF1p55, CG4236, d-CAF1, dCAF-1, dCAF-1 p55, DmelCG4236, dNURF, MSI1/RbAp48/CAC3/LIN-53, NURF, Nurf-55, NURF-55, Nurf55, p55, P55, p55/NURF-55, p55CAF1, RbAp48, nurf55, rbap48, MGC79922, mRbAp48, RBBP4, rbb4-2, zgc:55349, zgc:77854, wu:fb33a09, wu:fb40e10, MGC128413, RBBP-4, DKFZp469A0122

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to RBBP4 (AT3587a) on HeLa cell . [antibody concentration 10 ug/ml] RBBP4 monoclonal antibody (M02), clone 4A5 Western Blot analysis of RBBP4 expression in HeLa NE ( Cat # L013V3 ).

anti-Retinoblastoma Binding Protein 4 (RBBP4) antibody (Image 2)

Publications

Product: Ishimaru, Arakaki, Yoshida et al.: "Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy." in: The Journal of experimental medicine, Vol. 205, Issue 12, pp. 2915-27, 2008 (PubMed).

Li, Zhang, Yu et al.: "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis." in: The EMBO journal, Vol. 28, Issue 18, pp. 2763-76, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Li, Margueron, Ku et al.: "Jarid2 and PRC2, partners in regulating gene expression." in: Genes & development, Vol. 24, Issue 4, pp. 368-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).