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Valosin Containing Protein (vcp) (AA 1-589) antibody

Details for Product No. ABIN393752, Supplier: Log in to see
Antigen
  • ALS14
  • IBMPFD
  • TERA
  • p97
  • 3110001E05
  • CDC48
  • p97/VCP
  • p93
  • wu:fd16d05
  • wu:fj63d11
Epitope
AA 1-589
28
6
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
104
32
30
6
2
2
2
1
1
1
1
1
1
1
1
1
1
Host
Mouse
76
32
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
2
2
2
2
2
Application
Western Blotting (WB)
101
47
26
26
24
16
8
7
7
2
1
1
1
1
1
1
Supplier
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Immunogen VCP (AAH07562, 1 a.a. ~ 589 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A8
Isotype IgG2a kappa
Specificity VCP (AAH07562, 1 a.a. ~ 589 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VCP (vcp Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 71066 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Valosin Containing Protein (vcp) (AA 1-589) antibody (ABIN393752) VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in ...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Tang, Li, Li et al.: "A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants." in: The EMBO journal, Vol. 29, Issue 13, pp. 2217-29, 2010 (PubMed).

Olson, Wang, Pankratz et al.: "Centrosome-related genes, genetic variation, and risk of breast cancer." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 221-8, 2010 (PubMed).

Halawani, Tessier, Anzellotti et al.: "Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 17, pp. 6132-42, 2010 (PubMed).

Fernández-Sáiz, Buchberger: "Imbalances in p97 co-factor interactions in human proteinopathy." in: EMBO reports, Vol. 11, Issue 6, pp. 479-85, 2010 (PubMed).