Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody

Details for Product No. ABIN393761
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Antigen
Synonyms ARD1, ARD1A, DXS707, NATD, TE2, 6330548N22Rik, AU044684, NIPP1, ard-1, ard1, nipp-1, nipp1, ARD-1, NIPP-1, PRO2047, PPP1R8
Epitope
AA 1-236
(8), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(54), (35), (34), (17), (14), (12), (12), (7), (2), (2), (1)
Host
Mouse
(44), (6), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(44), (25), (10), (8), (7), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393761
450.00 $
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Immunogen ARD1 (AAH00308, 1 a.a. ~ 236 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B7-H4
Isotype IgG1 kappa
Specificity ARD1 (AAH00308, 1 a.a. ~ 236 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ARD1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26459 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: N-alpha-acetylation is one of the most common protein modifications that occurs during protein synthesis and involves the transfer of an acetyl group from acetyl-coenzyme A to the protein alpha-amino group. ARD1A, together with NATH (NARG1, MIM 608000), is part of a major N-alpha-acetyltransferase complex responsible for alpha-acetylation of proteins and peptides (Sanchez-Puig and Fersht, 2006 [PubMed 16823041]).

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody Immunofluorescence of monoclonal antibody to ARD1A on HeLa cell (antibody concentration 10 µg/mL). ARD1 monoclonal antibody (M01), clone 4B7-H4 Western Blot analysis of ARD1 expression in Hela NE.
anti-Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody (2) anti-Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody (Image 2)
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Arnesen, Starheim, Van Damme et al.: "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation." in: Molecular and cellular biology, Vol. 30, Issue 8, pp. 1898-909, 2010 (PubMed).

Seo, Cha, Park et al.: "Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation." in: Cancer research, Vol. 70, Issue 11, pp. 4422-32, 2010 (PubMed).

Lee, Ou, Lee et al.: "hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2920-30, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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