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Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody

Details for Product No. ABIN393761, Supplier: Log in to see
Antigen
  • ARD1
  • ARD1A
  • DXS707
  • NATD
  • TE2
  • 6330548N22Rik
  • AU044684
  • NIPP1
  • ard-1
  • ard1
  • nipp-1
  • nipp1
  • ARD-1
  • NIPP-1
  • PRO2047
  • PPP1R8
Epitope
AA 1-236
17
14
7
4
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
89
41
40
11
10
3
2
2
2
1
1
Host
Mouse
53
18
17
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
68
35
26
14
11
5
1
1
Supplier
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Immunogen ARD1 (AAH00308, 1 a.a. ~ 236 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B7-H4
Isotype IgG1 kappa
Specificity ARD1 (AAH00308, 1 a.a. ~ 236 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ARD1 (PPP1R8 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26459 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: N-alpha-acetylation is one of the most common protein modifications that occurs during protein synthesis and involves the transfer of an acetyl group from acetyl-coenzyme A to the protein alpha-amino group. ARD1A, together with NATH (NARG1, MIM 608000), is part of a major N-alpha-acetyltransferase complex responsible for alpha-acetylation of proteins and peptides (Sanchez-Puig and Fersht, 2006 [PubMed 16823041]).

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody (ABIN393761) Immunofluorescence of monoclonal antibody to ARD1A on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody (ABIN393761) anti-Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) (AA 1-236) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Lee, Ou, Lee et al.: "hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2920-30, 2010 (PubMed).

Seo, Cha, Park et al.: "Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation." in: Cancer research, Vol. 70, Issue 11, pp. 4422-32, 2010 (PubMed).

Arnesen, Starheim, Van Damme et al.: "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation." in: Molecular and cellular biology, Vol. 30, Issue 8, pp. 1898-909, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).