Coilin (COIL) (AA 477-576) antibody

Details for Product No. ABIN393763
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Antigen
Synonyms p80c, coil, CG8710, Coilin, Dmel\\CG8710, LOC100218802, F3F19.5, F3F19_5, CLN80, p80-coilin, C79982, Cln80, p80, wu:fb08h11, sph1
Epitope
AA 477-576
(8), (8), (6), (3), (1), (1), (1), (1)
Reactivity
Human
(31), (6), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(23), (10)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (15), (5), (5), (4), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 200 µL
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Catalog No. ABIN393763
450.00 $
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Immunogen COIL (NP_004636, 477 a.a. ~ 576 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B8
Isotype IgM kappa
Specificity COIL (NP_004636, 477 a.a. ~ 576 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name COIL
Background The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
Synonyms: CLN80, p80coilin coilin
Molecular Weight 62608 DA
Gene ID 8161
NCBI Accession NP_004636
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.

Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Coilin (COIL) (AA 477-576) antibody COIL monoclonal antibody (M05A), clone 4B8 Western Blot analysis of COIL expression in NIH/3T3.
Background publications Hong, Lee, Cho et al.: "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1." in: Biochemical and biophysical research communications, Vol. 371, Issue 2, pp. 256-60, 2008 (PubMed).

Bongiorno-Borbone, De Cola, Vernole et al.: "FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 15, pp. 2357-67, 2008 (PubMed).

Hearst, Gilder, Negi et al.: "Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines." in: Journal of cell science, Vol. 122, Issue Pt 11, pp. 1872-81, 2009 (PubMed).

Toyota, Davis, Cosman et al.: "Coilin phosphorylation mediates interaction with SMN and SmB'." in: Chromosoma, Vol. 119, Issue 2, pp. 205-15, 2010 (PubMed).

Zhao, Li, Bradfield et al.: "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature." in: BMC medical genetics, Vol. 11, pp. 96, 2010 (PubMed).

Validation Images
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