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Oxidative-Stress Responsive 1 (OXSR1) (Met18) antibody

Details for Product No. ABIN393773, Supplier: Log in to see
Antigen
  • 2210022N24Rik
  • 2810422B09Rik
  • AI462649
  • AW209236
  • mKIAA1101
  • Osr1
  • OSR1
  • OXSR1
  • zgc:55494
  • zgc:77321
Epitope
Met18
18
16
15
13
12
9
8
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
96
38
22
2
1
1
Host
Mouse
57
48
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
87
66
39
26
17
11
11
10
1
1
Supplier
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Immunogen OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C12
Isotype IgG Mix kappa
Specificity OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OXSR1 (OXSR1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58022 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Oxidative-Stress Responsive 1 (OXSR1) (Met18) antibody (ABIN393773) Immunofluorescence of monoclonal antibody to OXSR1 on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-Oxidative-Stress Responsive 1 (OXSR1) (Met18) antibody (ABIN393773) anti-Oxidative-Stress Responsive 1 (OXSR1) (Met18) antibody (Image 2)
Background publications Lee, Cobb, Goldsmith: "Crystal structure of domain-swapped STE20 OSR1 kinase domain." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 2, pp. 304-13, 2009

Villa, Deak, Alessi, van Aalten: "Structure of the OSR1 kinase, a hypertension drug target." in: Proteins, Vol. 73, Issue 4, pp. 1082-7, 2008

Richardson, Rafiqi, Karlsson, Moleleki, Vandewalle, Campbell, Morrice, Alessi: "Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 675-84, 2008

Barbe, Lundberg, Oksvold, Stenius, Lewin, Björling, Asplund, Pontén, Brismar, Uhlén, Andersson-Svahn: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008

Villa, Goebel, Rafiqi, Deak, Thastrup, Alessi, van Aalten: "Structural insights into the recognition of substrates and activators by the OSR1 kinase." in: EMBO reports, Vol. 8, Issue 9, pp. 839-45, 2007