Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1) antibody

Details for Product No. ABIN393774
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Antigen
Synonyms HAKAI, RNF188, zgc:55308, CBLL1
Reactivity
Human
(22), (8), (6), (2), (2), (1), (1)
Host
Mouse
(19), (4)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
(23), (7), (5), (3), (1), (1)
Pubmed 5 references available
Catalog no. ABIN393774
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen CBLL1 (NP_079090, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C2
Isotype IgG2a kappa
Specificity CBLL1 (NP_079090, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CBLL1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 54519 DA
Gene ID 12406
UniProt NP_079090
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Epithelial cell cadherin (CDH1, MIM 192090) is endocytosed as a consequence of tyrosine phosphorylation and ubiquitination. HAKAI is an E3 ubiquitin ligase (see UBE3A, MIM 601623) that mediates ubiquitination of the CDH1 complex.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

Suzuki, Yamashita, Shirota et al.: "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions." in: Genome research, Vol. 14, Issue 9, pp. 1711-8, 2004 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Figueroa, Kotani, Toda et al.: "Novel roles of hakai in cell proliferation and oncogenesis." in: Molecular biology of the cell, Vol. 20, Issue 15, pp. 3533-42, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Hosts (19), (4)
Reactivities (22), (8), (6), (2), (2), (1), (1)
Applications (23), (7), (5), (3), (1), (1)
Epitopes (5), (4), (3)
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