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DUSP5 antibody (Dual Specificity Phosphatase 5) (AA 286-385)

Details for Product anti-DUSP5 Antibody No. ABIN393778, Supplier: Log in to see
Antigen
  • DUSP5
  • wu:fc03b11
  • wu:fc86e02
  • MGC84792
  • dusp
  • hvh3
  • DUSP
  • HVH3
  • Cpg21
  • Gm337
Epitope
AA 286-385
15
10
8
4
2
2
2
Reactivity
Human
49
9
7
Host
Mouse
33
20
Clonality (Clone)
Monoclonal ()
Conjugate
This DUSP5 antibody is un-conjugated
3
3
2
2
2
2
1
Application
Immunofluorescence (IF), Western Blotting (WB)
45
30
14
7
5
5
3
2
1
1
Supplier
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Immunogen DUSP5 (NP_004410, 286 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C8
Isotype IgG1 kappa
Specificity DUSP5 (NP_004410, 286 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DUSP5 (DUSP5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42107 DA
Gene ID 12406
NCBI Accession NP_004410
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DUSP5 antibody (Dual Specificity Phosphatase 5) (AA 286-385) (ABIN393778) Immunofluorescence of to DUSP5 on HeLa cell . DUSP5 monoclonal antibody (M03), clone ...
Immunohistochemistry (IHC) image for anti-DUSP5 antibody (Dual Specificity Phosphatase 5) (AA 286-385) (ABIN393778) anti-Dual Specificity Phosphatase 5 (DUSP5) (AA 286-385) antibody (Image 2)
Background publications Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Grasset, Gobert-Gosse, Mouchiroud et al.: "Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5." in: Journal of leukocyte biology, Vol. 87, Issue 1, pp. 127-35, 2010 (PubMed).

Pramanik, Chun, Garnaas et al.: "Dusp-5 and Snrk-1 coordinately function during vascular development and disease." in: Blood, Vol. 113, Issue 5, pp. 1184-91, 2009 (PubMed).