Dual Specificity Phosphatase 5 (DUSP5) (AA 286-385) antibody

Details for Product No. ABIN393778
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Antigen
Synonyms DUSP5, wu:fc03b11, wu:fc86e02, MGC84792, dusp, hvh3, DUSP, HVH3, Cpg21, Gm337
Epitope
AA 286-385
(9), (7), (4), (2), (1), (1)
Reactivity
Human
(45), (17), (14)
Host
Mouse
(32), (15)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(34), (21), (10), (7), (4), (4), (3), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393778
450.00 $
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Immunogen DUSP5 (NP_004410, 286 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C8
Isotype IgG1 kappa
Specificity DUSP5 (NP_004410, 286 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DUSP5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42107 DA
Gene ID 12406
NCBI Accession NP_004410
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Dual Specificity Phosphatase 5 (DUSP5) (AA 286-385) antibody Immunofluorescence of to DUSP5 on HeLa cell . DUSP5 monoclonal antibody (M03), clone 4C8 Western Blot analysis of DUSP5 expression in K-562.
anti-Dual Specificity Phosphatase 5 (DUSP5) (AA 286-385) antibody (2) anti-Dual Specificity Phosphatase 5 (DUSP5) (AA 286-385) antibody (Image 2)
Background publications Pramanik, Chun, Garnaas et al.: "Dusp-5 and Snrk-1 coordinately function during vascular development and disease." in: Blood, Vol. 113, Issue 5, pp. 1184-91, 2009 (PubMed).

Grasset, Gobert-Gosse, Mouchiroud et al.: "Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5." in: Journal of leukocyte biology, Vol. 87, Issue 1, pp. 127-35, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

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