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Sin3A-Associated Protein, 30kDa (SAP30) antibody
Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||SAP30 (NP_003855, 131 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: Sin3A-associated protein, 30kDa|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||SAP30 (NP_003855, 131 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||23306 DA|
Background: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Signaling, Protein Modifications, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Doyon, Cayrou, Ullah et al.: "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation." in: Molecular cell, Vol. 21, Issue 1, pp. 51-64, 2006 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
Szafranski, Schindler, Taudien et al.: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, 2008 (PubMed).
Sichtig, Körfer, Steger: "Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex." in: Archives of biochemistry and biophysics, Vol. 467, Issue 1, pp. 67-75, 2007 (PubMed).
Viiri, Jänis, Siggers et al.: "DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides." in: Molecular and cellular biology, Vol. 29, Issue 2, pp. 342-56, 2008 (PubMed).
|Hosts||Rabbit (4), Mouse (2)|
|Reactivities||Human (6), Cow (Bovine) (2), Dog (Canine) (2), Mouse (Murine) (2), Rat (Rattus) (2), Chicken (1), Xenopus laevis (1)|
|Applications||Western Blotting (WB) (6), ELISA (3), Immunofluorescence (IF) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)|
|Epitopes||Internal Region (1), N-Term (1)|