Metastasis Associated 1 (MTA1) antibody

Details for Product No. ABIN393787
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Synonyms fj99h01, mta1, wu:fj99h01, zgc:56396
(62), (33), (31), (2), (2), (1), (1), (1)
(42), (13), (9)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(53), (29), (10), (8), (4), (2), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN393787
Quantity 0.1 mg
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Immunogen MTA1 (NP_004680, 601 a.a. ~ 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D5
Isotype IgG3 kappa
Specificity MTA1 (NP_004680, 601 a.a. ~ 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MTA1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 80788 DA
Gene ID 12406
UniProt NP_004680
Research Area Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Metastasis Associated 1 (MTA1) antibody MTA1 monoclonal antibody (M01), clone 4D5 Western Blot analysis of MTA1 expression in Hela NE.
anti-Metastasis Associated 1 (MTA1) antibody (2) anti-Metastasis Associated 1 (MTA1) antibody (Image 2)
Background publications Bui-Nguyen, Pakala, Sirigiri et al.: "Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 6980-6, 2010 (PubMed).

Li, Pakala, Reddy et al.: "Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 10044-52, 2010 (PubMed).

Chokas, Trivedi, Lu et al.: "Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13304-13, 2010 (PubMed).

Li, Ohshiro, Khan et al.: "Requirement of MTA1 in ATR-mediated DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 19802-12, 2010 (PubMed).

Van Rechem, Boulay, Pinte et al.: "Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells." in: Molecular and cellular biology, Vol. 30, Issue 16, pp. 4045-59, 2010 (PubMed).

Hosts (42), (13), (9)
Reactivities (62), (33), (31), (2), (2), (1), (1), (1)
Applications (53), (29), (10), (8), (4), (2), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (9), (8), (3), (1), (1), (1), (1), (1), (1), (1)
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