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ASF1 Anti-Silencing Function 1 Homolog B (S. Cerevisiae) (ASF1B) (AA 1-203) antibody

Details for Product No. ABIN393788, Supplier: Login to see
Antigen
  • ASF1B
  • asf1
  • MGC89345
  • asf1-b
  • asf1a
  • asf1a-b
  • asf1ab
  • cia-ii
  • CIA-II
  • 1700003K02Rik
  • AA409591
  • asf1b
  • fc68a10
  • wu:fc68a10
  • zgc:77178
  • F16F17.110
  • F16F17_110
  • SGA01
  • SGA1
  • anti- silencing function 1b
Epitope
AA 1-203
4
3
2
2
1
1
1
1
Reactivity
Human
34
15
15
4
1
1
1
1
1
1
Host
Mouse
28
6
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
28
19
9
2
2
1
Supplier
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Immunogen ASF1B (AAH07726, 1 a.a. ~ 203 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D5-2C2
Isotype IgG1 kappa
Specificity ASF1B (AAH07726, 1 a.a. ~ 203 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ASF1B (ASF1B Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 22434 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jasencakova, Scharf, Ask et al.: "Replication stress interferes with histone recycling and predeposition marking of new histones." in: Molecular cell, Vol. 37, Issue 5, pp. 736-43, 2010 (PubMed).

Peng, Nogueira, Vogel et al.: "Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2461-6, 2010 (PubMed).

Pilyugin, Demmers, Verrijzer et al.: "Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases." in: PLoS ONE, Vol. 4, Issue 12, pp. e8328, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).