ASF1 Anti-Silencing Function 1 Homolog B (S. Cerevisiae) (ASF1B) antibody

Antigen: ASF1 Anti-Silencing Function 1 Homolog B (S. Cerevisiae) (ASF1B)

Synonyms: CIA-II, FLJ10604, AA409591, 1700003K02Rik, fc68a10, zgc:77178, wu:fc68a10, ASF1B, MGC139875, ANTI- SILENCING FUNCTION 1B, F16F17.110, F16F17_110, SGA01, SGA1, asf1, MGC89345

Clonality: Monoclonal (4D5-2C2)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393788

Additional Information

Alternative name: ASF1B

Gene ID: 55723

Immunogen: ASF1B (AAH07726, 1 a.a. ~ 203 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 4D5-2C2

Description: Other names: CIAII, FLJ10604 ASF1 anti-silencing function 1 homolog B (S. cerevisiae)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ASF1B (AAH07726, 1 a.a. ~ 203 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 22434 DA

Comments:

Background: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure

Restrictions: For Research Use only

Publications

Product: Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Pilyugin, Demmers, Verrijzer et al.: "Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases." in: PLoS ONE, Vol. 4, Issue 12, pp. e8328, 2009 (PubMed).

Peng, Nogueira, Vogel et al.: "Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2461-6, 2010 (PubMed).

Jasencakova, Scharf, Ask et al.: "Replication stress interferes with histone recycling and predeposition marking of new histones." in: Molecular cell, Vol. 37, Issue 5, pp. 736-43, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).