ASF1 Anti-Silencing Function 1 Homolog B (S. Cerevisiae) (ASF1B) (AA 1-203) antibody

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Antigen
  • ASF1B
  • asf1
  • MGC89345
  • asf1-b
  • asf1a
  • asf1a-b
  • asf1ab
  • cia-ii
  • CIA-II
  • 1700003K02Rik
  • AA409591
  • asf1b
  • fc68a10
  • wu:fc68a10
  • zgc:77178
  • F16F17.110
  • F16F17_110
  • SGA01
  • SGA1
  • anti- silencing function 1b
  • ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
  • anti-silencing function 1b
  • ASF1 anti-silencing function 1 homolog B
  • anti-silencing function 1B histone chaperone
  • ASF1 anti-silencing function 1 homolog Ba (S. cerevisiae)
  • histone chaperone ASF1B
  • ASF1B
  • asf1b
  • Asf1b
  • asf1ba
Alternatives
anti-Human ASF1 Anti-Silencing Function 1 Homolog B (S. Cerevisiae) antibody for ELISA
Epitope
AA 1-203
29
2
2
2
2
2
2
1
Reactivity
Human
58
16
15
4
2
2
1
1
1
1
1
1
1
1
Host
Mouse
32
27
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
49
38
9
3
3
2
2
1
1
1
Options
Supplier
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Immunogen ASF1B (AAH07726, 1 a.a. ~ 203 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D5-2C2
Isotype IgG1 kappa
Specificity ASF1B (AAH07726, 1 a.a. ~ 203 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ASF1B (ASF1B Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 22434 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure
Pathways Regulation of Cell Size
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jasencakova, Scharf, Ask, Corpet, Imhof, Almouzni, Groth: "Replication stress interferes with histone recycling and predeposition marking of new histones." in: Molecular cell, Vol. 37, Issue 5, pp. 736-43, 2010 (PubMed).

Peng, Nogueira, Vogel, Kristie: "Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2461-6, 2010 (PubMed).

Pilyugin, Demmers, Verrijzer, Karch, Moshkin: "Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases." in: PLoS ONE, Vol. 4, Issue 12, pp. e8328, 2009 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).