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PRKAA1 antibody (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit) (AA 451-551)

Details for Product anti-PRKAA1 Antibody No. ABIN393792, Supplier: Log in to see
Antigen
  • Prkaa1
  • ampk
  • ampka1
  • PRKAA1
  • AMPK
  • AMPKa1
  • AMPKalpha1
  • AI194361
  • AI450832
  • AL024255
  • C130083N04Rik
  • cb116
  • im:7154392
  • sb:cb130
  • wu:fa94c10
  • AMPK1
Alternatives
anti-Human PRKAA1 antibody for Immunoprecipitation
Epitope
AA 451-551
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5
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3
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1
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Reactivity
Human
237
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8
5
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Host
Mouse
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1
Clonality (Clone)
Monoclonal ()
Conjugate
This PRKAA1 antibody is un-conjugated
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10
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Application
Immunofluorescence (IF), Western Blotting (WB)
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93
88
35
34
27
19
10
9
4
4
2
1
1
Supplier
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Immunogen PRKAA1 (AAH12622, 451 a.a. ~ 551 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D8
Isotype IgG2a kappa
Specificity PRKAA1 (AAH12622, 451 a.a. ~ 551 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PRKAA1 (PRKAA1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 62808 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways AMPK Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PRKAA1 antibody (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit) (AA 451-551) (ABIN393792) Immunofluorescence of monoclonal antibody to PRKAA1 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-PRKAA1 antibody (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit) (AA 451-551) (ABIN393792) anti-Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) (AA 451-551) antibody (Image 2)
Background publications Jassim, Fernø, Theisen et al.: "Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia." in: Pharmacopsychiatry, Vol. 44, Issue 1, pp. 15-20, 2011 (PubMed).

Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Slattery, Herrick, Lundgreen et al.: "Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1." in: Carcinogenesis, Vol. 31, Issue 9, pp. 1604-11, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).