serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (AA 374-483) antibody

Details for Product No. ABIN393802
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Antigen
Synonyms
Shmt, mShmt, LRRGT00032, shmt1, MGC53442, zgc:66171, zgc:77524, SHMT1, Shmt1, CSHMT, SHMT, AI324848, AI385541, C81125, mshmt, mshmt1, mshmt2, MEL-32, SHMT2, F20D10.50, F20D10_50, SERINE HYDROXYMETHYLT ... show more
Shmt, mShmt, LRRGT00032, shmt1, MGC53442, zgc:66171, zgc:77524, SHMT1, Shmt1, CSHMT, SHMT, AI324848, AI385541, C81125, mshmt, mshmt1, mshmt2, MEL-32, SHMT2, F20D10.50, F20D10_50, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TRANSHYDROXYMETHYLTRANSFERASE, STM, serine transhydroxymethyltransferase 1 show less
Epitope
AA 374-483
(10), (8), (7), (3), (2), (2), (2), (1), (1)
Reactivity
Human
(34), (3), (3), (1), (1), (1)
Host
Mouse
(23), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(34), (20), (14), (5), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393802
450.00 $
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Immunogen SHMT1 (NP_004160, 374 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F9
Isotype IgG1 kappa
Specificity SHMT1 (NP_004160, 374 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SHMT1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53083 DA
Gene ID 12406
NCBI Accession NP_004160
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (AA 374-483) antibody SHMT1 monoclonal antibody (M01), clone 4F9 Western Blot analysis of SHMT1 expression in HeLa on formalin-fixed paraffin-embedded human colon tissue.
anti-serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (AA 374-483) antibody (2) anti-serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (AA 374-483) antibody (Image 2)
Background publications Vijayakrishnan, Houlston: "Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis." in: Haematologica, Vol. 95, Issue 8, pp. 1405-14, 2010 (PubMed).

Summers, Mitchell, Stanislawska-Sachadyn et al.: "Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 8, pp. 679-88, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Porter, Basu, Hubbard et al.: "Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism." in: Environmental research, Vol. 110, Issue 6, pp. 580-7, 2010 (PubMed).

Validation Images
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