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Details for Product No. ABIN393802

serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) antibody

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Antigen
Synonyms
Shmt, mshmt, C81125, mshmt1, mshmt2, AI324848, AI385541, mShmt, LRRGT00032, MEL-32, CSHMT, SHMT, SHMT2, F20D10.50, F20D10_50, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TR ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393802
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen SHMT1 (NP_004160, 374 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F9
Isotype IgG1 kappa
Specificity SHMT1 (NP_004160, 374 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SHMT1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53083 DA
Gene ID 12406
UniProt NP_004160
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Vijayakrishnan, Houlston: "Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis." in: Haematologica, Vol. 95, Issue 8, pp. 1405-14, 2010 (PubMed).

Summers, Mitchell, Stanislawska-Sachadyn et al.: "Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 8, pp. 679-88, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Porter, Basu, Hubbard et al.: "Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism." in: Environmental research, Vol. 110, Issue 6, pp. 580-7, 2010 (PubMed).

Alternatives for antigen "serine Hydroxymethyltransferase 1 (Soluble) (SHMT1)", type "Antibodies"
Hosts (13), (7)
Reactivities (19), (2), (2), (1), (1), (1)
Applications (20), (8), (5), (3), (2), (1)
Epitopes (5), (3), (2), (2), (2), (2), (1), (1)
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