|+1 404 474 4654|
|+1 888 205 9894 (TF)|
serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) antibody
|Synonyms||Shmt, mshmt, C81125, mshmt1, mshmt2, AI324848, AI385541, mShmt, LRRGT00032, shmt1, MGC53442, MGC66171, zgc:66171, zgc:77524, SHMT1, MGC137164, MEL-32, Shmt1, DKFZp469J1932|
Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Quantity||0.1mg (1 mg/ml)|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||SHMT1 (NP_004160, 374 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: CSHMT, MGC15229, MGC24556, SHMTserine hydroxymethyltransferase 1 (soluble)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||SHMT1 (NP_004160, 374 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||53083 DA|
Background: This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Vijayakrishnan, Houlston: "Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis." in: Haematologica, Vol. 95, Issue 8, pp. 1405-14, 2010 (PubMed).
Summers, Mitchell, Stanislawska-Sachadyn et al.: "Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 8, pp. 679-88, 2010 (PubMed).
Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).
Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).
Porter, Basu, Hubbard et al.: "Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism." in: Environmental research, Vol. 110, Issue 6, pp. 580-7, 2010 (PubMed).
|Hosts||Rabbit (11), Mouse (2)|
|Reactivities||Human (11), Mouse (Murine) (3), Rat (Rattus) (3), Arabidopsis thaliana (1), Spinach (Spinacia oleracea) (1)|
|Applications||Western Blotting (WB) (13), ELISA (7), Immunohistochemistry (IHC) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2)|
|Epitopes||N-Term (3), AA 1-483 (1), N-Term,AA 18-47 (1)|